Neuroimaging APT CEST V.1.0 imaging solution

• MRI

This case report shows the possibility to provide earlier accurate diagnosis through Amide Proton Transfer weighted after fluid suppression (F.S. APTw).

Multiparametric MRI in brain tumours is an invaluable methodology for obtaining in-depth information for the structural and functional tissue features guiding the differential diagnosis and assisting the tumour staging. Each MRI parametric maps provides crucial information for the different histomolecular tumour substrates, whereas the ‘tier-like’ interpretation of the combined structural-functional outputs helps the radiologist to reach an accurate diagnosis.

This case report shows the potential added value of Amide Proton Transfer (APT) contrast in the discrimination between radio-induced toxicity lesions and tumor progression in brain metastatic disease.

The young patient presented a first hyperthermic convulsive seizure. One month later, he presented another tonic-clonic episode with left hemicorporeal seizure lasting less than 5 minutes. Another month later, he had a tonic-clonic seizure again, without fever but complicated by status epilepticus. Afterwards, a CT scan showed a right parietal lesion, and he was transferred to the Necker- Enfants Malades hospital for a brain and spinal-cord MRI. The spinal-cord MRI did not reveal any metastases.